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2010-03-17ZeitschriftenartikelLow hepatitis B immunogenicity of a hexavalent vaccine widely used in Germany: results of the German Health Survey for Children and Adolescents, 2003–2006 The success of childhood vaccination against hepatitis B relies on persistence of immunity into adolescence and adulthood. In 2000, two hexavalent vaccines with a hepatitis B component (Hexavac®, Infanrix hexa®) were ...
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2010-08-04ZeitschriftenartikelVirulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses ...
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2009-05-01ZeitschriftenartikelbdhA-patD operon as a virulence determinant, revealed by a novel large-scale approach for identification of Legionella pneumophila mutants defective for amoeba infection. Legionella pneumophila, the causative agent of Legionnaires' disease, is an intracellular parasite of eukaryotic cells. In the environment, it colonizes amoebae. After being inhaled into the human lung, the bacteria infect ...
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2010-01-27ZeitschriftenartikelIncreasing Occurrence of Multidrug-Resistance in Acinetobacter baumannii Isolates From Four German University Hospitals, 2002–2006 Background: Acinetobacter baumannii can cause severe infections, mainly in critically ill inpatients. Treatment is complicated by multidrug-resistance (MDR). In Germany, to date, little is known on the extent of MDR in A. ...
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2005-11-01ZeitschriftenartikelErfassung der gesundheitsbezogenen Lebensqualität mit dem deutschen SF-8 Ein Vergleich der telefonischen und postalischen BefragungsmethodeIm Rahmen eines Vergleiches telefonischer und postalischer Befragungsmethoden wurde der SF-8 als Instrument zur Messung der gesundheitsbezogenen Lebensqualität bei Erwachsenen eingesetzt. Die aus 1690 Personen im Alter ...
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2011-02-25ZeitschriftenartikelOperationalizing multimorbidity and autonomy for health services research in aging populations - the OMAHA study Background: As part of a Berlin-based research consortium on health in old age, the OMAHA (Operationalizing Multimorbidity and Autonomy for Health Services Research in Aging Populations) study aims to develop a conceptual ...
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2010-01-13ZeitschriftenartikelHLA–B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility Objective: Although the products of the HLA subtypes B*2705 and B*2709 differ only in residue 116 (Asp versus His) within their peptide-binding grooves, they are differentially associated with inflammatory rheumatic ...
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2010-01-25ZeitschriftenartikelEvaluation of poliovirus antibody titers in orally vaccinated semi-captive chimpanzees in Uganda Background: To understand immunological responses in chimpanzees vaccinated with live-attenuated vaccine (oral polio vaccine; OPV), serum neutralizing antibodies against poliovirus types 1, 2, and 3 were investigated over ...
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2010-07-01ZeitschriftenartikelRückblick: Epidemiologie und Infektionsschutz im zeitlichen Verlauf der Influenzapandemie (H1N1) 2009 On April 21, 2009, for the first time the isolation of a new variant of the influenza virus A(H1N1) taken from two patients in California was reported (CDC 2009). The newly isolated virus was a reassortant from four ...
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2011-02-16ZeitschriftenartikelHighly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly Background: The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains. Although p6 is located within one of the most polymorphic ...
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2010-11-01ZeitschriftenartikelVirological diagnosis of dengue fever in Jeddah, Saudi Arabia: Comparison between RT-PCR and virus isolation in cell culture A total of 233 serum samples were collected from patients presenting to King Abdulaziz University Hospital with suspected cases of Dengue Fever (DF) from 2006 to 2008. Dengue virus was successfully isolated from 70 samples ...
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2011-02-15ZeitschriftenartikelA clinical trial alert tool to recruit large patient samples and assess selection bias in general practice research Background: Many research projects in general practice face problems when recruiting patients, often resulting in low recruitment rates and an unknown selection bias, thus limiting their value for health services research. ...
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2010-01-23ZeitschriftenartikelTick burden on European roe deer (Capreolus capreolus) In our study we assessed the tick burden on roe deer (Capreolus capreolus L.) in relation to age, physical condition, sex, deer density and season. The main objective was to find predictive parameters for tick burden. In ...
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2009-04-22ZeitschriftenartikelGenetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007. The variability between respiratory syncytial virus (RSV) strains is one of the features of RSV infections that might contribute to the ability of the virus to infect people repeatedly and cause yearly outbreaks. To study ...
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2010-02-28ZeitschriftenartikelThe death-scene investigation The death-scene investigation is an important and increasingly recognized step in the process of diagnosing Sudden Infant Death Syndrome (SIDS). According to current definitions, information from death-scene investigations ...
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2011-01-03ZeitschriftenartikelAnionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus The aim of the present study was to characterise anti-vaccinia virus activities of anionic exopolysaccharides TK V3 isolated from cyanobacterium Arthrospira platensis and an exopolysaccharide isolated from the rhodophyt ...
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2010-11-01ZeitschriftenartikelGesundheitliche Entwicklungen und Trends in Ost- und Westdeutschland Seit der Wiedervereinigung Deutschlands vor 20 Jahren wurden enorme gesellschaftliche Anstrengungen unternommen, um die Lebensverhältnisse in den neuen Bundesländern an die in den alten anzugleichen. In vielen Bereichen ...
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2008-04-11ZeitschriftenartikelTabakkonsum und Passivrauchbelastung von Jugendlichen Smoking and Passive Smoking Exposure in Young PeopleEinleitung: Die Verbreitung und mögliche Einflussfaktoren des Tabakkonsums und der Passivrauchbelastung von Jugendlichen werden analysiert. Methoden: Datenbasis ist eine Teilstichprobe des Kinder- und Jugendgesundheitssurveys ...
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2011-01-28ZeitschriftenartikelArbeitslosigkeit, soziale Unterstützung und gesundheitliche Beschwerden: Ergebnisse aus der GEDA-Studie 2009 Unemployment, Social Support and Health Problems—Results of the GEDA Study in Germany, 2009Hintergrund: Es ist dokumentiert, dass Arbeitslose im Vergleich zu Erwerbstätigen häufiger von Gesundheitsproblemen betroffen sind, und soziale Unterstützung die Bewältigung von Arbeitslosigkeitserfahrungen erleichtert. ...
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2011-02-10ZeitschriftenartikelHighly sensitive detection of the group A Rotavirus using Apolipoprotein H-coated ELISA plates compared to quantitative real-time PCR Background: The principle of a capture ELISA is binding of specific capture antibodies (polyclonal or monoclonal) to the surface of a suitable 96 well plate. These immobilized antibodies are capable of specifically binding ...