edoc.rki.de - Open Access Publikationsserver: Recent submissions
Now showing items 11001-11020 of 12257
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2010-05-01ZeitschriftenartikelDifferential expression of human endogenous retrovirus K transcripts in primary human melanocytes and melanoma cell lines after UV irradiation. Human endogenous retroviruses (HERVs) are discussed as causative agents of various diseases including cancers. Expression of endogenous retroviral sequences can be induced by ultraviolet (UV) light, which is also considered ...
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2011-05-17ZeitschriftenartikelDietary patterns are associated with cardiometabolic risk factors in a representative study population of German adults Studies that investigated complex actual eating behaviours of the general population and their relation to cardiometabolic risk markers are sparse. We aimed to identify dietary patterns within a nationally representative ...
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2011-10-22ZeitschriftenartikelErste Richtlinien der Gendiagnostik-Kommission (GEKO)
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2011-10-22ZeitschriftenartikelVibrio-Infektionen durch Lebensmittel und Meerwasser Das Netzwerk „VibrioNet“ stellt sich vorVibrionen sind salzliebende Bakterien, die in Oberflächen- und Küstengewässern sowie Meerestieren weltweit verbreitet sind. In vielen Ländern stellen pathogene Vibrio-Spezies eine der Hauptursachen von bakteriell verursachten ...
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2011-10-22ZeitschriftenartikelDas Zentrum für Krebsregisterdaten (ZfKD) im Robert Koch-Institut (RKI) in Berlin Krebserkrankungen stellen in Deutschland die zweithäufigste Todesursache dar. Zur Beschreibung der Krebsbelastung in der deutschen Bevölkerung ist die Erhebung und Auswertung von Daten über Auftreten und Häufigkeiten von ...
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2011-10-22ZeitschriftenartikelHealthcare-associated infections in long-term care facilities (HALT) Ergebnisse aus Deutschland im Rahmen einer europäischen PrävalenzstudieDie Ursachen für die Entstehung von Infektionen bei alten Menschen, die in Heimen leben, sind vielfältig. Die oftmals daraus resultierende Antibiotikatherapie kann zudem zu einer Selektion multiresistenter Erreger führen ...
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2012-05-08ZeitschriftenartikelBlood pressure and lipid management fall far short in persons with type 2 diabetes: results from the DIAB-CORE Consortium including six German population-based studies Background: Although most deaths among patients with type 2 diabetes (T2D) are attributable to cardiovascular disease, modifiable cardiovascular risk factors appear to be inadequately treated in medical practice. The ...
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2012-08-13ZeitschriftenartikelSingle mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1 Background: The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation ...
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2012-09-27ZeitschriftenartikelConfidence-based Somatic Mutation Evaluation and Prioritization Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms. However, NGS-based somatic mutation ...
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2012-11-01ZeitschriftenartikelUnchanged Severity of Influenza A(H1N1)pdm09 Infection in Children during First Postpandemic Season We conducted a nationwide hospital-based prospective study in Germany of influenza A(H1N1)pdm09 cases among children
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2012-10-02ZeitschriftenartikelScope and Impact of International Research in Human Pluripotent Stem Cells In a recent study published in this journal it was claimed that the rate of publications from US-based authors in the human embryonic stem cell (hESC) research field was slowing or even declining from 2008 to 2010. It was ...
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2011-09-25ZeitschriftenartikelOverview of Biologic Response Modifiers in Infectious Disease The conventional treatment of infectious agents is increasingly encountering antimicrobial resistance. This resistance has led to an intense search for novel treatment modalities for infectious diseases. Elucidation of the ...
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2010-04-01ZeitschriftenartikelCharacterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C. Background: Porcine endogenous retroviruses (PERVs) pose a potential risk for xenotransplantation using pig cells, tissues or organs. A special threat comes from viruses generated by recombination between human-tropic ...
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2011-01-01ZeitschriftenartikelTowards an AIDS vaccine: The transmembrane envelope protein as target for broadly neutralizing antibodies Although the development of an effective vaccine is the main goal in the fight against AIDS, all attempts by numerous laboratories to develop a vaccine have failed so far. In addition, it is still unclear whether cytotoxic ...
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2010-05-04ZeitschriftenartikelIsotopologue Profiling of Legionella pneumophila Role of Serine and Glucose as Carbon SubstratesLegionella pneumophila (Lp) is commonly found in freshwater habitats but is also the causative agent of Legionnaires' disease when infecting humans. Although various virulence factors have been reported, little is known ...
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2010-05-04ZeitschriftenartikelBestimmung von Impfquoten und Inzidenzen von Erkrankungen anhand von Daten der Kassenärztlichen Vereinigungen Determination of Vaccination Coverage and Disease Incidence using Statutory Health Insurance DataHintergrund: Im Rahmen des KV-Sentinels, einem gemeinsamen Projekt des Robert Koch-Instituts und der 17 Kassenärztlichen Vereinigungen, werden seit 2004 pseudonymisierte Abrechnungsdaten von den Kassenärztlichen Vereinigungen ...
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2011-09-14ZeitschriftenartikelInfluenza B Virus With Modified Hemagglutinin Cleavage Site as a Novel Attenuated Live Vaccine Background: Both pandemic and interpandemic influenza is associated with high morbidity and mortality worldwide. Seasonal epidemics are caused by both influenza A and B virus strains that cocirculate with varying predominance ...
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2010-09-24ZeitschriftenartikelCharacterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics. Yersinia are Gram-negative, rod-shaped facultative anaerobes, and some of them, Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis, are pathogenic in humans. Rapid and accurate identification of ...
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2009-11-18ZeitschriftenartikelDeletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency The immediate-early 1 (IE1) and IE2 proteins encoded by the major immediate-early (MIE) transcription unit of cytomegaloviruses are thought to play key roles in the switch between latent- and lytic-cycle infection. Whilst ...
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2011-02-01ZeitschriftenartikelRegional differences in body fat distributions among people with comparable body mass index: a comparison across six German population-based surveys Introduction: The mortality of circulatory diseases of the German population varies considerably across regions. The comparison of the regional distributions of cardiovascular risk factors can provide clues to the reasons ...